The Santa Fe Railroad Depot, located at Tulare and Santa Fe Streets in downtown Fresno, is constructed in a simple Mission Revival style. Arches and tile roofs comprise the general architectural features. Many of the windows are framed with segmental arched openings. The roofs are of medium pitch and nearly all are hipped. There is a single tower and several turrets, all capped with pyramidal tiled roofs. There are a few shaped gable ends of curvilinear outline. Only a few sculptural ornaments appear, with the most prominent one located at the tower on the west elevation. Otherwise, the building is almost completely free of any sculptural ornamentation.

Re-View was contracted to replicate the historic windows on the project. Over the years, many of the windows had been replaced by non-historic replacements. Re-View used parts and pieces from original remnants and original architectural drawings to establish the designs of the replicated windows.